+84 028 37242160 / +84 0334009659
Nhà điều hành ĐHQG TP.HCM, P. Linh Trung, Q. Thủ Đức, TP. HCM
Title
Dr
Department
(1) Division of Biochemistry and Molecular Biology, (2) Research Center for Genetics and Reproductive Health
Position
Full time
Qualifications
| Degree | Duration | Institution | Major | Thesis Title |
| Bachelor | 2000-2004 | University of Science, Vietnam National University HCMC | Bitotechnology | Detection and Genotyping of HPV virus |
| MSc-PhD | 2004-2009 | Synkyunkwan University, South Korea | Life Science | Molecular mechanisms underlying inhibitory effect of Fucoidan on cytokine-induced inflammation in glioma cells. |
Professional Engagement
| Duration | Institution | Position |
| 11/2014 – now | School of Medicine – Vietnam National University HCMC, Vietnam | Lecturer and Researcher |
| 03/2014 – 11/2014 | Dong Nai University of Technonogy, Vietnam | Lecturer |
| 10/2012 -02/2014 | School of Medine – Tan Tao University, Vietnam | Lecturer and Researcher |
| 01/2012 – 10/2012 | School of Medicine, Deakin University, Australia | Postdoctoral research fellow |
| 03/2010 – 06/2011 | Virology division, Animal, Plant and Fisheries Quarantine and Inspection Agency, South Korea | Postdoctoral research fellow |
| 2009-2010 | School of Pharmacy, Synkyunkwan University, South Korea | Postdoctoral research fellow |
Key responsibilities
- Lecturer of Division of Biochemistry and Molecular Biology: teaching
subjects related to Cell Biology and Molecular Biology - Researcher of Research Center for Genetics and Reproductive Health:
doing research in the field of Medical Genetics
Research interests
Dr. Hằng obtained her Ph.D in
Pharmacy in Sungkyunkwan University, South Korea in 2009 and did her
postdoctoral training in molecular and cellular immunology at QIA, South Korea,
and then, at Deakin University, Australia from 2009-2012. From 2005-2009, Dr.
Hằng’s research focused on molecular mechanisms underlying pathogenesis of (1)
Alzheimer’s disease and (2) H1N1 influenza virus infection. Dr. Hằng returned to
Vietnam in 2012 and started her new research on genetics and molecular
mechanisms of severe epilepsy syndromes, especially of Dravet syndrome. Dr. Hằng
recent interest also includes the applying of modern molecular techniques,
especially of high-throughput sequencing, for genetic testing.
Publications
In international journals
Do Hang, Hye-Sook Choi, Se-Chan Kang, Kyung-Ran Kim, Eun-Soo Sohn, Mi-Hyun Kim, Suhkneung Pyo, Eunwha Son. Effects of Fucoidan on NO Production and Phagocytosis of Macrophages and the Proliferation of Neuron Cells. Journal of Food Science and Nutrition (2005) 10 (4): 344-348. (Journal title now changed to: Preventive Nutrition and Food Science)
| No. | Authors, Title, Journal, Volume | ISSN |
| 1 | Do Hang, Hye-Sook Choi, Se-Chan Kang, Kyung-Ran Kim, Eun-Soo Sohn, Mi-Hyun Kim, Suhkneung Pyo, Eunwha Son. Effects of Fucoidan on NO Production and Phagocytosis of Macrophages and the Proliferation of Neuron Cells. Journal of Food Science and Nutrition (2005) 10 (4): 344-348. (Journal title now changed to: Preventive Nutrition and Food Science) | 2287-8602 |
| 2 | Hye-Sook Choi, Do Hang, Seong-Jun Cho, Se-Chan Kang, Eun-Soo Sohn, Sang-Pil Lee, Suhk-Neung Pyo, Eun-Wha Son. Immunomodulatory Activity of Pine Needle (Pinus densiflora) Extracts in Macrophages. Journal of Food Science and Nutrition (2006) 11(2): 105-109. (Journal title now changed to: Preventive Nutrition and Food Science) | 2287-8602 |
| 3 | Hye-Sook Choi, Do Hang, Mi-Kyeong Choi, Sung-Ryul Lee, Suhkneung Pyo, Eunwha Son, Mi-Hyun Kim. The Effects of Boron on the Proliferation of Osteoblastic and Neuroblastoma Cells. Journal of Food Science and Nutrition (2005) 10(4): 353-356. (Journal title now changed to: Preventive Nutrition and Food Science) | 2287-8602 |
| 4 | Hye-Rim Lee, Hang Do, Sung-Ryul Lee, Eun-Soo Sohn, Suhk-Neung Pyo, Eun-Wha Son. Effects of Fucoidan on Neuronal Cell Proliferation: Association with NO Production through the iNOS Pathway. Journal of Food Science and Nutrition (2007) 12(2): 74-78 (Journal title now changed to: Preventive Nutrition and Food Science) | 2287-8602 |
| 5 | Eunwha Son#, Hang Do#, Hae-Mi Joo, and Suhkneung Pyo (# Co-first author). Induction of alkaline phosphatase activity by L-ascorbic acid in human osteoblastic cells: a potential role for CK2 and Ikaros. Nutrition. (2007) 23:745–753 | 0899-9007 |
| 6 | Eun-Hwa Sohn, Hang Do, Nam-Sung Kang et al. Effects of Non-saponin Red Ginseng Components on the Function of Brain Cells J. Ginseng Res. (2008) 32: 62-66 | 1226-8453 |
| 7 | Hang Do, Eun Hwa Sohn. Suhkneung Pyo. Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK, AP-1, and IRF-1, and depends on up-regulation of scavenger receptor B1 expression in TNF-α and IFN-γ-stimulated C6 glioma cells. Journal of Nutritional Biochemistry. (2010) 21 : 671-679 | 0955-2863 |
| 8 | Hang Do, Nam-Sung Kang, Suhkneung Pyo, Timothy R. Billiar, Eun-Hwa Sohn. 2010. Differential regulation by fucoidan of IFN-γ-induced NO production in glial cells and macrophages. Journal of Cellular Biochemistry. (2010) 111 : 1337–1345 | 1097-4644 |
| 9 | Yeun-Kyung Shin, Soon-Seek Yoon, Jae-Young Song, Jun-Bae Kim, Do Thi Thu Hang, Jin-Woo Park, Min-Young Kim, Seong-Hee Kim, Choi-Kyu Park and O-Soo Li. One-Step Multiplex Reverse-Transcriptase PCR for Detecting Pandemic (H1N1) 2009 Influenza Virus. J Vet Med Sci. (2010) 73 : 55-63 | 1347-7439 |
| 10 | Seung Namkoong , Se-Chan Kang , Hang Do , Ki-Hyo Jang , Seon-A Jang, Myoung-Gun Choung and Eun-Hwa Sohn. Immunomodulatory Effects of Supplementation with Extracts from the Marine Brown Alga Eisenia bicyclis on Macrophages. Korean J. Plant Res. (2011). 24(3) : 298-303. | 1226-3591 |
| 11 | Do Thi Thu Hang, Jae-Young Song, Min-Young Kim, Jin-Woo Park, and Yeun-Kyung Shin. Involvement of NF-κB in changes of IFN-γ-induced CIITA/MHC-II and iNOS expression by influenza virus in macrophages. Molecular Immunology. (2011) 48 : 1253-1262 | 0161-5890 |
| 12 | Do Thi Thu Hang, Eun-Jin Choi, Jae-Young Song, Sun-Ae Kim, Jeongeon Kwak and Yeun-Kyung Shin. Differential effect of prior influenza infection on Alveolar Macrophage phagocytosis of Staphylococcus aureus and Escherichia coli: Involvement of Interferon-gamma production. Microbiology and Immunology. (2011) 55(11):751-9 | 1348-0421 |
| 13 | Hyun Jung Koo, Seon-A Jang, Kwang-Hee Yang, Se Chan Kang, Seung Namkoong, Tae-Hyung Kim, Do Thi Thu Hang, Eun-Hwa Sohn. Effects of Red Ginseng on the regulation of cyclooxygenase-2 of spleen cells in whole-body gamma irradiated mice. Food and Chemical Toxicology. (2013) Dec;62:839-46 | 0278-6915 |
| 14 | Eun-Hwa Sohn, Hyun Jung Koo, Do Thi Thu Hang, Seon-A Jang, Seung Namkoong, Jung Dae Lim, Se Chan Kang. Protective effects of ellagic acid on ethanol-induced toxicity in hepatic HepG2 cells. Molecular and Cellular Toxicology (2013) 9: 249-256 | 2092-8467 |
| 15 | Hang Do, HJ Park, EH Sohn, BO Kim, SH Um, JH Kwak, EY Moon, DK Rhee, S Pyo. Ethanol induces cell cycle arrest and triggers apoptosis via Sp1-dependent p75NTR expression in human neuroblastoma cells. Cell biology and toxicology (2013) 29: 365-380. | 1573-6822 |
| 16 | Do Thi Thu Hang, Huynh Thi Thuy Kieu, Le Thi Khanh Van. Acute encephalopathy in Dravet syndrome: two case reports and literature review. Neurology Asia (2016) 21 : 181 – 18. |
1823-6138 |
| 17 | Thi Thu Hang Do, Diem My Vu, Thi Thuy Kieu Huynh, Thi Khanh Van Le, Eun-Hwa Sohn, Thieu Mai Thao Le, Huu Hao Ha, Chi Bao Bui. SCN1A gene mutation and adaptive functioning in 18 vietnamese with Dravet syndrome. J Clin Neurol (2017) 13:62-70. |
1738-6586 |
| 18 | Le Sy Vinh, Le Phan Hoang Truc, Le Thi Khanh Van, Huynh Thi Thuy Kieu, Do Thi Thu Hang. A mutation in GABRB3 associated with Dravet syndrome. Am J Med Genet A. (2017);173(8):2126-2131 | 1552-4833 |
| 19 | Asha Lakkavaram, Rachel J. Lundie, Hang Do, Alister C. Ward and Tania F. de Koning-Ward. Acute Plasmodium berghei Mouse Infection Elicits Perturbed Erythropoiesis With Features That Overlap With Anemia of Chronic Disease. Frontier in Microbology. April 2020 | Volume 11 | Article 702 | |
| 20 | Van LTK, Hien HTD, Kieu HTT, Hieu NLT, Vinh LS, Hoa G, Hang DTT. De novo homozygous variant of the SCN1A gene in a patient with severe Dravet syndrome complicated by acute encephalopathy. Neurogenetics. 2021 Mar 5. doi: 10.1007/s10048-021-00636-7. Epub ahead of print. PMID: 33674996. |
In National Journals
| No. | Authors, Title, Journal, Volume | ISSN |
| 1 | Lê Thị Khánh Vân, Huỳnh Thị Thúy Kiều, Nguyễn Huỳnh Bảo Ngân, Bùi Chí Bảo, Vũ Diễm My, Lê Thiều Mai Thảo, Đỗ Thị Thu Hằng. CA LÂM SÀNG: HỘI CHỨNG DRAVET VỚI ĐỘT BIẾN GEN SCN1A VÀ DIỄN BIẾN XẤU HIẾM GẶP SAU TRẠNG THÁI ĐỘNG KINH. Y Học Thành phố Hồ Chí Minh, Tập 19, Phụ bản của số 1, 2015. | 1859-1779 |
| 2 | Lê Võ Hồng Ngọc, Nguyễn Thị Dung, Đỗ Thị Thu Hằng, Hồ Trần Bản, Bùi Chí Bảo. Làm giàu trình tự toàn bộ exon của gen ARID1B trong u nguyên bào thần kinh. Y học thành phố Hồ Chí Minh. Năm:2016 Tập:20 Số:1 Chuyên đề:Nội khoa 2 Trang:144 | 1859-1779 |
| 3 | Bùi Chí Bảo, Tô Thùy Nhi, Châu Gia Các, Đỗ Thị Thu Hằng. Nghiên cứu biểu hiện của ALK trong u nguyên bào thần kinh ở người. Y học TP. Hồ Chí Minh, Phụ bản tập 20, Số 1, 2016. | 1859-1779 |
| 5 | Huu Phuc Nguyen, Do Thi Thu Hang, Quoc Trung Ly, Hoang ND Pham, Dang Quan Nguyen and Le Xuan Truong Nguyen. Targeting PI3K/AKT/mTOR signaling in Acute Myeloid Leukemia. Vietnam Journal of Science 2(2) (2015) 11-16. | 2374-8664 |
| 6 | Vũ Diễm My, Bùi Chí Bảo, Lê Thiều Mai Thảo, Huỳnh Thị Diệu Hiền, Đỗ Thị Thu Hằng. Xây dựng quy trình giải trình tự gen SCN1A bằng kỹ thuật giải trình tự Sanger. Y học Thành Phố Hồ Chí Minh, tập 20, số 4, 2016. | 1859-1779 |
| 7 | Huỳnh Thị Diệu Hiền, Lê Thị Khánh Vân, Huỳnh Thị Thúy Kiều, Đỗ Thị Thu Hằng. Khảo sát đột biến gen SCN1A trên nhóm bệnh nhi Việt Nam mắc hội chứng Dravet. Y học Thành phố Hồ Chí Minh, Phụ bản tập 20, số 6, 2016. | 1859-1779 |
| 8 | Trịnh Văn Bờ Em, Nguyễn Vạn Thông, Nguyễn Thị Thanh Kiều, Đỗ Thị Thu Hằng. Bước đầu nghiên cứu ứng dụng DNA tự do của thai trong máu mẹ (cffDNA) trong xét nghiệm trước sinh không xâm lấn đối với bệnh β-thalassemia. Tạp chí Khoa học ĐHQGHN: Khoa học Tự nhiên và Công nghệ, Tập 33, Số 1S (2017) 1-7. | 0866-8612 |
| 9 | Châu Thị Lệ, Nguyễn Vạn Thông, Võ Thanh Bình, Hoàng Thị Diễm Tuyết, Lê Nguyễn Vân Khanh, Phạm Hùng Vân, Nguyễn Hoài Nghĩa, Giang Hoa, Đỗ Thị Thu Hằng. Phát hiện đột biến β-thalassaemia có nguồn gốc từ cha sử dụng cffDNA trong máu mẹ kết hợp giải trình tự gen bằng phương pháp amplicon. Y Học TP. Hồ Chí Minh * Phụ Bản Tập 23 * Số 6 * 2019. 124-130 | |
| 10 | Lê Thị Khánh Vân, Lê Duy Thái Dương, Đỗ Thị Thu Hằng, Huỳnh Thị Thuý Kiều, Nguyễn Lê Trung Hiếu, Bùi Thị Thùy Dung, Nguyễn Thanh Vũ, Nguyễn Quốc Dũng, Huỳnh Thị Diệu Hiền. XÂY DỰNG QUY TRÌNH PHÁT HIỆN ĐỘT BIẾN ĐIỂM TRÊN GEN MECP2 Ở BỆNH NHI VIỆT NAM MẮC HỘI CHỨNG RETT. Tạp chí Tạp chí Phát triển Khoa học và Công nghệ – Khoa học Sức khoẻ. Tập 1- 2020. (Sci. Tech. Dev. J. – Health Sci.; 1(1):xxx-xxx) | |
| 11 | Nguyễn Thanh Vũ, Đỗ Thị Thu Hằng, Lê Thị Khánh Vân, Nguyễn Lê Trung Hiếu, Huỳnh Thị Diệu Hiền. NGUYÊN NHÂN DI TRUYỀN GÂY HỘI CHỨNG RETT: CHẨN ĐOÁN LÂM SÀNG VÀ CƠ HỘI ĐIỀU TRỊ. Tạp chí Y học Việt Nam, tập 495 – th¸ng 10 – sè 1 – 2020 |
In conferences
| TT | Authors, Title, Journal, Volume | Link |
| 1 | Hang Do, Hyesook Choi, Sungryul Lee, Haemi Joo, Hyerim Lee et al. CKII is involved in the regulation of Ikaros and ALP activity induced by L-ascorbic acid. Experimental Biology 2007 – Washington, DC (April 28–May 5, 2007). | http://www.fasebj.org/content/21/6/A1082.3.short |
| 2 | Eunwha Son, Sungryul Lee, Hyesook Choi, Hang Do, Hyunjung Koo, Jeongeun Huh, Sungjun Cho, Mihyun Kim, Dongkwon Rhee, and Suhkneung Pyo. Effects of high-dose magnesium and manganese supplementation on immune functions in ovariectomized rats. Experimental Biology 2007 – Washington, DC (April 28–May 5, 2007). |
http://www.fasebj.org/content/21/5/A378.1 |
| 3 | Eunwha Son, Hyesook Choi, Hang Do, Mihyun Kim, and Suhkneung Pyo. The effect of calcium status on the immune function of ovariectomized rat. Experimental Biology 2008 – ASPET’s Centennial Meeting – San Diego, CA (April 5–9, 2008) | http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/1099.2 |
| 4 | Eunwha Son, Jung-Dae Lim, Sulkyoung Park, Nam-Sung Kang, Hang Do, and Suhkneung Pyo. Immunomodulatory effects of beta-glucan from Coriolus versicolor on the phagocytosis of macrophages: involvement of SR-B1 expression. Experimental Biology 2008 – ASPET’s Centennial Meeting – San Diego, CA (April 5–9, 2008) |
http://www.fasebj.org/content/22/1_Supplement/1139.5 |
| 5 | Nam Sung Kang, Hang Thi Thu Do, Seon-A Jang, Suhkneung Pyo, and Eun Hwa Sohn. 2009. Fucoidan inhibits the expression iNOS induced by TNF- and IFN- in C6 glioma cells; Regulation by p38 MAPK, AP-1, IRF-1 and scavenger receptor B1. Experimental Biology ’09 (ASPET Annual Meeting) – New Orleans, LA (April 18-22, 2009) | http://www.fasebj.org/content/23/1_Supplement/739.20 |
| 6 | Hang Thi Thu Do, Nam Sung Kang, Suhkneung Pyo, Jung Dae Lim, Jae Cheol Lee, and Eun Hwa Sohn. Fucoidan regulates IFN- –induced NO and iNOS production differently in C6 glioma cells and RAW264.7 cells: the involvement of JAK/STAT, p38 activation and TNF- production. Experimental Biology ’09 (ASPET Annual Meeting) – New Orleans, LA (April 18-22, 2009) | http://www.fasebj.org/content/23/1_Supplement/739.21 |
| 7 |
Hye-Jin Park, Hang Do, Eun-Hwa Sohn, Dong-Kwon Rhee and Suhkneung Pyo. Ethanol-induced cell cycle arrest and apoptosis is mediated by sp1-dependent expression of p75NTR in neuroblastoma cells. Experimental Biology ’11 (ASPET Annual Meeting), Washington, DC (April 9-13, 2011) |
http://www.fasebj.org/content/25/1_Supplement/612.2.short |
| 8 |
Nguyen Dang Nam, Do Thi Thu Hang. Evaluation of localized corrosion in food industry by electrochemical methods. Proceeding of 2nd AFSSA Conference on Food Safety and Food Security. August 15 – 17, 2014. Dong Nai Province, Vietnam. |
|
| 9 |
D. Thi Thu Hang* – H. Thi Thuy Kieu – L. Thi Khanh Van. ACUTE ENCEPHALOPATHY IN TWO CHILDREN WITH DRAVET SYNDROME /Human Genome Meeting 2015 14 – 17 March 2015 Kuala Lumpur Convention Centre, Malaysia |
|
| 10 |
D. T. T. Hang* – B. Chi Bao – V. Diem My. MUTATIONS OF THE SCN1A GENE IN VIETNAMESE CHILDREN WITH DRAVET SYNDROME. Human Genome Meeting 2015 14 – 17 March 2015 Kuala Lumpur Convention Centre, Malaysia |
|
| 11 |
Thi-Thu-Hang Do*, Thi-Thuy-Kieu Huynh, Thi-Khanh-Van Le. Acute encephalopathy in Dravet syndrome: two case reports and discussion of risk factors. Asia Pacific Conference on Human Genetics 2015. 16th -19th September 2015 – Sheraton Hotel, Hanoi, Vietnam. |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563532/ |
| 12 |
Thi-Thu-Hang Do*, Thieu-Mai-Thao Le, ChiBao Bui, Diem-My Vu. SCN1A mutational analysis in 20 Vietnamese children with Dravet syndrome. Asia Pacific Conference on Human Genetics 2015. 16th -19th September 2015 – Sheraton Hotel, Hanoi, Vietnam. |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563513/ |
| 13 |
Do Thi Thu Hang, Huynh Thi Dieu Hien, Le Phan Hoang Truc. Whole exome sequencing identifies a heterozygous missense variant in the GABRB3 gene in a patient with a Dravet syndrome. International Conference on Biochemistry 2016. October 10-12, 2016 Kuala Lumpur, Malaysia. |
Hyperlink |
| 14 | Le Sy Vinh, Nguyen Duc Canh, Bui Ngoc Thang, Do Thi Thu Hang, Duong Quoc Chinh, Tran Cong Hoang, Le Ba Hong Minh, Pham Thi Dieu Linh. Genomedics: Whole exome analysis system for clinical studies. The 9th International Conference on Knowledge and Systems Engineering (KSE 2017). Hue, Vietnam October 19-21, 2017 | http://kse2017.dhsphue.edu.vn/acceptedpapers.aspx (0.1) |
| 15 | Nguyen Le Trung Hieu, Nguyen Thi Quynh Mai, Le Thi Khanh Van, Nguyen Thuy Minh Thu, Le Tran Anh Ngan, Huynh Thi Dieu Hien, Do Thi Thu Hang. A novel KCNQ2 gene mutation in a patient with self-limitted non-familial neonatal epilepsy: a case report. PA-11. BIOLOGY CONFERENCE 2020-Quy Nhơn. www.icisequynhon.com/conferences/2020/3rd-Biology | www.icisequynhon.com/conferences/2020/3rd-Biology |
| 16 | Nguyen Thi Quynh Mai. Nguyen Le Trung Hieu, Le Thi Khanh Van, Nguyen Thuy Minh Thu, Le Tran Anh Ngan, Huyenh Thi Dieu Hien, Do Thi Thu Hang. Gene mutational analysis by whole-exome sequencing of 48 Vietnamese patients with epileptic encephalopathy. [PB-09. BIOLOGY CONFERENCE 2020-Quy Nhơn. www.icisequynhon.com/conferences/2020/3rd-Biology |
www.icisequynhon.com/conferences/2020/3rd-Biology |