+84 028 37242160 ext. 3111
Nhà điều hành ĐHQG-HCM, P. Linh Trung, TP.Thủ Đức, TP.HCM
Title
PhD
Department
Department of Infectious Diseases
Position
Vice Head, Department of Infectious Diseases
Qualifications
- 1977 – 1983: University of Medicine and Pharmacy of HCM City,
Viet Nam- 1983: Medical Doctor (Viet Nam);
- 1983 – 1986: Internist, Department of Infectious Diseases,
University of Medicine and Pharmacy of HCM City, Viet Nam;- 1987: Diploma in Infectious Diseases (Viet Nam)
- 1996: London School of Hygiene and Tropical Medicine, UK;
- Diploma in Tropical Medicine and Hygiene;
- 1998: Master of Science in Medicine (Viet Nam);
- 2005 – 2009: Doctorate Candidate, Research School The Open
University, UK;- 2009: Doctor of Philosophy (The Open University, UK).
Honours, awards and grants
PUBLICATIONS
- Arnold K, Hien TT, Chinh NT, Phu NH, Mai PP.
A randomized comparative study of artemisinine (qinghaosu) suppositories and
oral quinine in acute falciparum malaria. Trans R Soc Trop Med
Hyg 1990; 84: 499-502.
- Hien TT, Arnold K, Vinh H, Cuong BM, Phu NH,
Chau TTH, Hoa NTM, Chuong LV, Mai NTH, Vinh NN, Trang TTM.
Comparison of artemisinin suppositories with intravenous artesunate and
intravenous quinine in the treatment of cerebral malaria. Trans
R Soc Trop Med Hyg 1992; 86: 582-583.
- Hien TT, Phu NH, Mai NTH, Chau TTH, Trang TTM,
Loc PP, Cuong BM, Dung NT, Vinh H, Waller DJ, White NJ. An open
randomised comparison of intravenous and intramuscular artesunate in severe
falciparum malaria. Trans R Soc Trop Med Hyg 1992;
86: 584‑585.
- Trang TTM, Phu NH, Vinh H, Hien TT, Cuong BM,
Chau TTH, Mai NTH, Waller DJ, White NJ. Acute renal failure in
patients with severe falciparum malaria. Clin Infect Dis
1992; 15: 874‑880.
- Phu NH, Day NPJ, Diep PT, Ferguson DJP, White
NJ. Intraleukocytic malaria pigment and prognosis in severe malaria.
Trans R Soc Trop Med Hyg 1995; 89: 200-204.
- Chau TTH, Day NPJ, Chuong LV, Mai NTH, Loc PP, Phu NH,
Bethell DB, Sinh DX, Hien TT, White NJ. Blackwater fever in Southern
Viet Nam: a prospective descriptive study of 50 cases.
Clin Infect Dis 1996; 23: 1274-1281.
- Day NPJ, Phu NH, Bethell DB, Mai NTH, Chau TTH,
Hien TT, White NJ. The effects of dopamine and adrenaline infusions
on acid-base balance and systemic haemodynamics in severe infection.
Lancet 1996; 348: 219-223.
- Day NPJ, Diep PT, Ly PT, Sinh DX, Loc PP, Chuong LV, Chau TTH, Mai NTH,
Bethell DB, Phu NH, Hien TT, White NJ.
Clearance kinetics of parasites and pigment-containing leukocytes in severe
malaria. Blood 1996; 88: 4694-4700.
- Hien TT, Day NPJ, Phu NH, Mai NTH, Chau TTH, Loc
PP, Sinh DX, Chuong LV, Vinh H, Waller DJ, Peto TEA, White NJ. A
controlled trial of artemether or quinine in Vietnamese adults with severe
falciparum malaria. N Engl J Med 1996; 335: 76-83.
- Mai NTH, Day NPJ, Chuong LV, Waller DJ, Phu NH,
Bethell DB, Hien TT, White NJ. Post-malaria neurological syndrome.
Lancet 1996; 348: 917-921.
- Ha Vinh, Huong NN, Ha TTB, Cuong BM, Phu NH,
Chau TTH, Quoi PT, Arnold K, Hien TT. Severe and complicated malaria
treated with artemisinin, artesunate, or artemether in Viet Nam.
Trans R Soc Trop Med Hyg 1997; 91: 465-467.
- Day NPJ, Phu NH, Loc PP. Malaria and
acute renal failure. J R Coll Phys London 1997; 31:
146-148.
- Taylor AM, Day NPJ, Sinh DX, Loc PP, Mai TTH, Chau TT, Phu NH,
Hien TT, White NJ. Reactive nitrogen intermediates and outcome in
severe adult malaria. Trans R Soc Trop Med Hyg 1998;
92: 170-175.
- Turner GDH, Chuong LV, Mai NTH, Chau TTH, Phu NH,
Bethell DB, Wyllie S, Louwrier K, Fox SB, Gatter KC, Day NPJ, Hien TT, White
NJ, Berendt AR. Systemic endothelial activation occurs in both mild
and severe malaria. Am J Pathol 1998; 152:
1477-1487.
- Brown H, Hien TT, Day NPJ, Mai NTH, Chuong LV, Chau TTH, Loc PP,
Phu NH, Bethell D, Farrar JJ, Gatter KC, White NJ, Turner G.
Evidence of blood-brain barrier dysfunction in human cerebral malaria.
Neuropathol Appl Neurobiol 1999; 25: 331-340.
- Day NPJ, Hien TT, Schollaardt T, Loc PP, Chuong LV, Chau TTH, Mai NTH,
Phu NH, Sinh DX, White NJ, Ho M. The prognostic and
pathophysiologic role of pro- and anti-inflammatory cytokines in severe
malaria. J Infect Dis 1999; 180: 1288-1297.
- Silamut K, Phu NH, Whitty C, Turner GDH,
Louwrier K, Mai NTH, Simpson JA, Hien TT, White NJ. A quantitative
analysis of the microvascular sequestration of malaria parasites in the
human brain. Am J Path 1999; 155: 395-410.
- Gamble J, Bethell DB, Day NP, Loc PP, Phu NH,
Gartside IB, Farrar JJ, White NJ. Age-related changes in
microvascular permeability: a significant factor in the susceptibility of
children to shock? Clin Sci 2000; 98: 211-216.
- Parry CM, Diep TS, Wain J, Hoa NTT, Gainsborough M, Nga LTD, Davies C,
Phu NH, Hien TT, White NJ, Farrar JJ. Nasal carriage in
Vietnamese children of Streptococcus pneumoniae resistant to
multiple antimicrobial agents. Antimicro Agents Chemothe
2000; 44: 484-488.
- Day NPJ, Phu NH, Mai NTH, Bethell DB, Chau TTH,
Loc PP, Chuong LV, Sinh DX, Solomon T, Haywood G, Hien TT, White NJ.
Effects of dopamine and epinephrine infusions on renal hemodynamics in
severe malaria and severe sepsis. Crit Care Med 2000; 28:
1353-1362.
- Day NP, Phu NH, Mai NTH, Chau TTH, Loc PP,
Chuong LV, Sinh DX, Holloway P, Hien TT, White NJ. The
pathophysiologic and prognostic significance of acidosis in severe adult
malaria. Crit Care Med 2000; 28: 1833-1840.
- Kissinger E, Hien TT, Hung NT, Nam ND, Tuyen NL, Dinh BV, Mann C,
Phu NH, Loc PP, Simpson JA, White NJ, Farrar JJ.
Clinical and neurophysiological study of the effects of multiple doses of
artemisinin on brain-stem function in Vietnamese patients. Am J
Trop Med Hyg 2000; 63: 48-55.
- Medana IM, Day NP, Hien TT, Mai NTH, Bethell D, Phu NH,
Farrar JJ, Esiri MM, White NJ, Turner GD. Axonal injury in cerebral
malaria. Am J Pathol 2002; 160: 655-666.
- Medana IM, Hien TT, Day NP, Phu NH, Mai NTH,
Chuong LV, Chau TTH, Taylor A, Salahifar H, Stocker R, Smythe G, Turner GDH,
Farrar JJ, White NJ, Hunt NH. The clinical significance of
cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in
severe malaria. J Infec Dis 2002; 185: 650-656.
- Medana IM, Mai NTH, Day NPJ, Hien TT, Bethell D, Phu NH,
Farrar JJ, White NJ, Turner GDH. Cellular stress and injury
responses in the brains of adult Vietnamese patients with fatal
Plasmodium falciparum malaria. Neuropathol Appl
Neurobiol. 2000; 27: 421-433.
- Chau TTH, Mai NTH, Phu NH, Luxemburgur C, Chuong
LV, Loc PP, Trang TTM, Vinh H, Cuong BM, Waller DJ, Sinh DX, Day NPJ, Hien
TT, White NJ. Malaria in injection drug abusers in Viet Nam.
Clin Infec Dis 2002; 34: 1317-1322.
- Thwaites GE, Chau TTH, Strepniewska K, Phu NH,
Chuong LV, Sinh DX, White NJ, Parry CM, Farrar JJ. Diagnosis of
adult tuberculous meningitis by use of clinical and laboratory features.
Lancet 2002; 360: 1287-1292.
- Phu NH, Hien TT, Mai NTH, Chau TTH, Chuong LV,
Loc PP, Winearls C, Farrar JJ, White NJ, Day N. Haemofiltration and
peritoneal dialysis in infection-associated acute renal failure in Vietnam.
N Engl J Med 2002; 347: 895-902.
- Dung NM, Kneen R, Kiem N, Bethell DB, Phu NH,
Solomon T, Chau TTH, Mai NTH, Day NPJ, White NJ. Treatment of severe
diphtheric myocarditis by temporary insertion of a cardiac pacemaker.
Clin Infec Dis 2002; 35: 1425-1429.
- Thwaites GE, Chau TTH, Caws M, Phu NH, Chuong
LV, Sinh DX, Drobniewski F, White NJ, Parry CM, Farrar JJ. Isoniazid
resistance, mycobacterial genotype and outcome in Vietnamese adults with
tuberculous meningitis. Int J Tuberc Lung Dis 2002; 6:
865-871.
- Pongponratn E, Turner GDH, Day NPJ, Phu NH,
Simpson JA, Stepniewka K, Mai NTH, Viriyavejakul P, Looareesuwan S, Hien TT,
Ferguson DJP, White NJ. An ultrastructural study of the brain in
fatal Plasmodium falciparum malaria. Am J Trop Med Hyg
2003; 69: 345-359.
- Hien TT, Turner GDH, Mai NTH, Phu NH, Bethell D,
Blakemore WF, Cavanagh JB, Dayan A, Medana I, Weller RO, Day NPJ, White NJ.
Neuropathological assessment for artemether-treated severe malaria.
Lancet 2003; 362: 295-296.
- Thwaites GE, Simmons C, Quyen NTH, Chau TTH, Mai PP, Dung NT,
Phu NH, White NJ, Hien TT, Farrar JJ. Pathophysiology
and prognosis in Vietnamese adults with tuberculous meningitis.
J Infec Dis. 2003;188 (8): 1105-1115.
- Hien TT, Davis TME, Chuong LV, Ilett KF, Sinh DX, Phu NH,
Agus C, Chiswell GM, White NJ, Farrar J. Comparative
Pharmacokinetics of Intramuscular Artesunate and Artemether in Patients with
Severe Falciparum Malaria. Antimicro Agents Chemothe 2004;
48: 4234-4239.
- Dondorp AM, Chau TTH, Phu NH, Mai NTH, Loc PP,
Chuong LV, Sinh DX, Taylor A, Hien TT, White NJ, Day NP.
Unidentified acids of strong prognostic significance in severe malaria.
Crit Care Med 2004; 32(8): 1683-1688.
- Thwaites GE, Caws M, Chau TT, Dung NT, Campbell JI, Phu NH,
Hien TT, White NJ, Farrar JJ. Comparison of Conventional
Bacteriology with Nucleic Acid Amplification (Amplified Mycobacterium Direct
Test) for Diagnosis of Tuberculous Meningitis before and after Inception of
Antituberculosis Chemotherapy. J Clin Microbiol. 2004;
42(3): 996-1002.
- Urban BC, Hien TT, Day NP, Phu NH, Roberts R,
Pongponratn E, Jones M, Mai NTH, Dethell D, Turner GDH, Ferguson D, White
NJ, Roberts DJ. Fatal Plasmodium falciparum malaria causes specific
patterns of splenic architectural disorganization. Infec and
Immu 2005; 73(4):1986-1994.
- Medana IM, Lindert R-B, Wurster U, Hien TT, Day NPJ, Phu NH,
Mai NTH, Chuong LV, Chau TTH, Turner GDH, Farrar JJ, White NJ.
Cerebrospinal fluid levels of markers of brain parenchymal damage in
Vietnamese adults with severe malaria. Trans R Soc
Trop Med Hyg 2005; 99: 610-617.
- German AC, Myint KSA, Mai NTH, Pomeroy I, Phu NH,
Tzartos J, Winter P, Collett J, Farrar J, Barrett A, Kipar A, Esiri MM,
Solomon T. A preliminary neuropathological study of Japanese
encephalitis in human and a mouse model. Trans R Soc
Trop Med Hyg 2006; 100: 1135-1145.
- Mai NTH, Chau TTH, Thwaites G, Chuong LV, Sinh DX, Nghia HDT, Tuan PQ,
Phong ND, Phu NH, Diep TS, Chau NVV, Duong NM,
Campbell J, Schultz C, Parry C, Torok E, White N, Chinh NT, Hien TT,
Stepniewska K, Farrar JJ. Dexamethasone in Vietnamese Adolescents
and Adults with Bacterial meningitis. N Engl J Med 2007;
357: 2431-2440.
- Medana IM, Day NPJ, Hien TT, Mai NTH, Dethell D, Phu NH, Turner
GDH, Farrar JJ, White NJ, Esiri MM. Cerebral calpain in fatal
falciparum malaria. Neuropathol Appl Neurobiol
2007; 33:179-192.
- Green JA, Chau TTH, Farrar JJ, Mai NTH, Phu NH,
Sinh DX, Nghia HDT, Chuong LV, Hien TT, Friedland JS, Thwaites GE.
Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations
and clinical outcomes in tuberculous meningitis. Plos ONE 2009;
4(9): e7277.
- Dung NM, Turtle L, Chong WK, Mai NTH, Thao TT, Thuy TT, Kneen R,
Phu NH, Wills B, Farrar J, Das K, Solomon T. An
evaluation of the usefulness of neuroimaging for the diagnosis of Japanese
encephalitis. J Neuro 2009.
- Mai NTH, Tuan TV, Wolbers M, Hoang DM, Nga TV, Chau TTH, Chuong LV, Sinh
DX, Nghia HDT, Phong ND, Phu NH, Diep TS, Hang HTT,
Chau NVV, Farrar J, Schultsz C, Hien TT, Simmons CP. Immunological
and biochemical correlates of adjunctive dexamethasone in Vietnamese adults
with bacterial meningitis. Clin Infec Dis 2009; 49:
1387-1392.
- Nguyen Hoan Phu. Clinical and
pathophysiological aspects of severe falciparum malaria. PhD
Thesis. The Open University, UK. 23 November 2009.
- Phu NH, Tuan PQ, Day N, Mai NTH, Chau TTH,
Chuong LV, Sinh DX, White NJ, Farrar J, Hien TT. Randomized
controlled trial of artesunate or artemether in Vietnamese adults with
severe falciparum malaria. Malaria J 2010; 9:97.
- Hanson J, Lee SJ, Mohanty S, Faiz MA, Anstey NM, Charunwatthana P, Yunus
EB, Mishra SK, Tjitra E, Price RN, Rahman R, Nosten F, Htut Y, Hoque G, Chau
TTH, Phu NH, Hien TT, White NJ, Day NPJ, Dondorp AM.
A simple score to predict the outcome of severe malaria in adults.
Clin Infec Dis 2010; 50: 679-685.
- O’Riordan S, Hien TT, Miles K, Allen A, Quyen NN, Hung NQ, Anh DQ, Tuyen LN, Khoa DB, Thai CQ, Triet DM, Phu NH, Dunstan S, Peto T, Clegg J, Farrar J, Weatherall D. Large scale screening for haemoglobin disorders in southern Vietnam: implications for avoidance and management. Br J Haematol 2010; 150: 359-364.
- Niederer HA, Willcocks LC, Rayner TF, Yang W, Lau YL, Williams TN, Scott JA, Urban BC, Peshu N, Dunstan SJ, Hien TT, Phu NH, Padyukov L, Gunnarsson I, Svenungsson E, Savage CO, Watts RA, Lyons PA, Clayton DG, Smith KG. Copy number, linkage disequilibrium and disease association in the FCGR locus. Hum Mol Genet 2010 June: 1-13.
- Chau TTH, Mai NTH, Phu NH, Nghia HDT, Chuong LV, Sinh DX, Duong VA, Diep PT, Campbell JI, Baker S, Hien TT, Lalloo DG, Farrar JJ, Day JN. A prospective descriptive study of cryptococcal meningitis in HIV uninfected patients in Vietnam – high prevalence of Cryptococcus neoformans var grubii in the absence of underlying disease. BMC Infec Dis 2010; 10:199.
- Nghia HDT, Tu LTP, Wolbers M, Thai CQ, Hoang NVM, Nga TVT, Thao LTP,
Phu NH, Chau TTH, Sinh DX, Diep TS, Hang HTT, Hoang T,
Campbell J, Chau NVV, Chinh NT, Dung NV, Hoa NT, Spratt BG, Hien TT, Farrar
J, Schultsz C. Risk factors of Streptococcus suis infection
in Vietnam. A case-control study. PloS ONE 2011 6(3):
e17604.
- Torok ME, Yen NT, Chau TT, Mai NT, Phu NH, Mai
PP, Dung NT, Chau NV, Bang ND, Tien NA, Minh NH, Hien NQ, Thai PV, Dong DT,
Anh do TT, Thoa NT, Hai NN, Lan NN, Lan NT, Quy HT, Dung NH, Hien TT, Chinh
NT, Simmons CP, de Jong M, Wolbers M, Farrar JJ. Timing of
initiation of antiretroviral therapy in human immunodeficiency virus
(HIV)—associated tuberculous meningitis. Clin Infect Dis
2011; 52: 1384-1387.
- Phu NH, Hanson J, Bethell D, Mai NTH, Chau TTH,
Chuong LV, Loc PP, Sinh DX, Dondorp A, White N, Hien TT, Day N. A
retrospective analysis of the haemodynamic and metabolic effects of fluid
resuscitation in Vietnamese adults with severe falciparum malaria.
PloS ONE 2011 6(10): e25523.
- Dunstan SJ, Farrar J, Hang NT, Clark TG, Day N, Jeffreys A, Kwatkowski
DP, O’Riordan SE, Phu NH, Quyen NTN, Rockett K,
Simmons CP, Small KS, Teo YY, Thai CQ, Hien TT. Variation in human
genes encoding adhesion and proinflammatory molecules are associated with
severe malaria in the Vietnamese. Genes immun 2012; 13:
503-508.
- Hien TT, Nhien NTT, Phu NH, Boni MF, Thanh NV,
Ca NTN, Thai LH, Thai CQ, Toi PV, Thuan PD, Long LT, Dong LT, Merson L,
Dolecek C, Stepniewska K, Ringwald P, White NJ, Farrar J, Wolbers M.
In vivo susceptibility of Plasmodium falciparum to artesunate in
Binh Phuoc province, Vietnam. Malaria J 2012; 11:355.
- Phu NH, Mai NTH, Nghia HDT, Chau TTH, Loc PP,
Thai LH, Phuong TM, Thai CQ, Manh DNH, Chau NVV, Nga TVT, Campbell J, Baker
S, Whitehorn J. Fatal consequences of freshwater pearl diving.
Lancet 2013; 381:176.
- Day JN, Chau TTH, Wolbers M, Mai PP, Dung NT, Mai NH, Phu NH,
Nghia HD, Phong ND, Thai CQ, Thai LH, Chuong LV, Sinh DX, Duong VA, Hoang
TN, Diep PT, Campbell JI, Sieu TPM, Baker SG, Chau NVV, Hien TT, Lalloo DG,
Farrar JJ. Combination Antifungal Therapy for Cryptococcal
Meningitis. N Engl J Med 2013; 368:1291-1302.
- Prapansilp P, Medana I, Mai NTH, Day NPJ, Phu NH,
Yeo TW, Hien TT, White NJ, Anstey NM, Turner GDH. A
clinicopathological correlation of the expression of the angiopoietin-Tie-2
receptor pathway in the brain of adults with Plasmodium falciparum malaria.
Malaria J 2013; 12:50.
- Lee JC, Espeli M, Anderson CA, Linterman MA, Pocock JM, Naomi JW,
Roberts R, Viatte S, Fu B, Hien TT, Phu NH, Wesley
E, Edwards C, Ahmad T, Mansfield JC, Gearry R, Dunstan S, Williams TN,
Barton A, Vinuesa CG, UK IBD Genetics Consortium, Parkes M, Lyons PA, Smith
KGC. Human SNP links differential outcomes in inflammatory and
infectious disease to a FOXO3-regulated pathway. Cell
2013; 155:57-69.
- Hanson J, Lee SJ, Mohanty S, Faiz MA, Anstey NM, Price RN,
Charunwatthana P, Yunus EB, Mishra SK, Tjitra E, Rahman R, Nosten F, Htut Y,
Maude RJ, Chau TTH, Phu NH, Hien TT, White NJ, Day
NPJ, Dondorp AM. Rapid clinical assessment to facilitate the triage
of adults with falciparum malaria, aretrospective analysis.
PloS ONE 2014; 9(1): e87020.
- Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, Sreng S,
Anderson JM, Mao S, Sam B, Sopha C, Chuor CM, Nguon C, Sovannaroth S,
Pukrittayakamee S, Jittamala P, Chotivanich K, Chutasmit K, Suchatsoonthorn
C, Runcharoen R, Hien TT, Nhien NTT, Thanh NV, Phu NH,
Htut Y, Han KT, Aye KH, Mokuolu OA, Olaosebikan RR, Folaranmi OO, Mayxay M,
Khanthavong M, Hongvanthong P, Newton PN, Onyamboko MA, Fanello CI, Tshefu
AK, Mishra N, Valecha N, Phyo AP, Nosten F, Yi P, Tripura R, Borrmann S,
Bashraheil M, Peshu J, Faiz MA, Ghose A, Hossain MA, Samad R, Rahman MR,
Hasan MM, Islam A, Miotto O, Amato R, MacInnis B, Stalker J,
Kwiatkowski DP, Bozdech Z, Jeeyapant A, Cheah PY, Sakulthaew T, Chalk J,
Intharabut B, Silamut K, Lee SJ, Vihokhern B, Kunasol C, Imwong M, Tarning
J, Taylor WJ, Yeung S, Woodrow CJ, Flegg JA, Das D, Smith J, Venkatesan M,
Plowe CV, Stepniewska K, Guerin PJ, Dondorp AM, Day NP, White NJ, for the
Tracking Resistance to Artemisinin Collaboration (TRAC). Spread of
Artemisinin Resistance in Plasmodium falciparum Malaria.
N Engl J Med 2014; 371: 411-423.
- Rockett KA, Clarke GM, Fitzpatrick K, Hubbart C, Jeffreys AE, Rowlands
K, Craik R, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F,
Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B,
Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A,
Koram KA, Wilson MD, Enimil A, Evans J, Amodu O, Olanyyan S, Apinjoh T,
Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN,
Manjurano A, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux
M, Dunstan SJ, Phu NH, Quyen NTN, Thai CQ, Hien TT,
Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TME,
Michon P, Mueller I, Green A, Molloy S, Johnson KJ, Kerasidou A, Cornelius
V, Hart L, Vanderwal A, SanJoaquin M, Band G, Si LQ, Pirinen M, Sepulveda N,
Spencer CCA, Clark TG, Agbenyega T, Achidi E, Doumbo O, Farrar J, Marsh K,
Taylor T, Kwiatkowski DP. (Malaria Genomic Epidemiology Network).
Reappraisal of known malaria resistance loci in a large multicenter study.
Nature Genetics 2014; 46: 1197-1204.
- Hanson J, Phu NH, Hasan MU, Charunwatthana P,
Plewes K, Maude RJ, Prapansilp P, Kingston HWF, Mishra SK, Mohanty S, Price
RN, Faiz MA, Dondorp AM, White NJ, Hien TT, Day NPJ. The Clinical
Implications of Thrombocytopenia in Adults with Severe Falciparum Malaria: A
Retrospective Analysis. BMC Med. 2015; 13:97.
- Heemskerk AD, Bang ND, Mai NTH, Chau TTH, Phu NH,
Loc PP, Chau NVV, Hien TT, Dung NH, Lan NTN, Lan NH, Lan NN, Phong LT, Vien
NN, Hien NQ, Yen NTB, Ha DTM, Day JN, Caws M, Merson L, Thinh TTV, Wolbers
M, Thwaites GE, Farrar JJ. Intensified Antituberculosis Therapy in
Adults with Tuberculous Meningitis. N Engl J Med 2016;
374: 124-134.
- Thuan PD, Ca NTN, Toi PV, Nhien NTT, Thanh NV, Anh ND, Phu NH,
Thai CQ, Thai LH, Hoa NT, Dong LT, Loi MA, Son DH, Khanh TTN, Dolecek C,
Nhan HT, Wolbers M, Thwaites G, Farrar J, White NJ, Hien TT. A
Randomized Comparison of Chloroquine versus Dihydroartemisinin-Piperaquine
for the Treatment of Plasmodium vivax Infection in Viet Nam. Am
J Trop Med Hyg 2016; 94: 879-885.
- Mai NTH, Phu NH, Tan LV, McBride A, Nghia HDT,
Thanh TT, Hong NTT, Heemskerk D, Day J, Vincent A, Chau NVV, Thwaites G.
First reported cases of anti-NMDA receptor encephalitis in Vietnamese
adolescents and adults. J of the Neur Scien 2017;
373: 250–253.
- Angela McBride, Chau TTH, Hong NTT, Mai NTH, Anh NT, Thanh TT, Van TTH,
Xuan LT, Sieu TPM, Thai LH, Chuong LV, Sinh DX, Phong ND, Phu NH,
Day J, Nghia HDT, Hien TT, NVV Chau, Thwaites G, Tan LV.
Angiostrongylus cantonensis Is an
Important Cause of Eosinophilic Meningitis in Southern Vietnam.
Clin Infect Dis 2017; 64(12): 1784–7.
- Mai NTH, Phu NH, Nhu LNT, Hong NTT, Hanh NHH,
Nguyet LA, Phuong TM, McBride A, Ha DQ, Nghia HDT, Chau NVV, Thwaites G, Tan
LV. Central Nervous System Infection Diagnosis by
Next-Generation Sequencing: A Glimpse Into the
Future? Open Forum Infectious Diseases® 2017Mar
4;4(2):ofx046. doi: 10.1093/ofid/ofx046. eCollection 2017 Spring.
- Geraldine M Clarke, Kirk Rockett, Katja Kivinen, Christina Hubbart, Anna
E Jeffreys, Kate Rowlands, Muminatou Jallow, David J Conway, Kalifa A
Bojang, Margaret Pinder, Stanley Usen, Fatoumatta Sisay-Joof, Giorgio
Sirugo, Ousmane Toure, Mahamadou A Thera, Salimata Konate, Sibiry Sissoko,
Amadou Niangaly, Belco Poudiougou, Valentina D Mangano, Edith C Bougouma,
Sodiomon B Sirima, David Modiano, Lucas N Amenga-Etego, Anita Ghansah,
Kwadwo A Koram, Michael D Wilson, Anthony Enimil, Jennifer Evans, Olukemi K
Amodu, Subulade Olaniyan, Tobias Apinjoh, Regina Mugri, Andre Ndi, Carolyne
M Ndila, Sophie Uyoga, Alexander Macharia, Norbert Peshu, Thomas N Williams,
Alphaxard Manjurano, Nuno Sepu´ lveda, Taane G Clark, Eleanor Riley, Chris
Drakeley, Hugh Reyburn, Vysaul Nyirongo, David Kachala, Malcolm Molyneux,
Sarah J Dunstan, Nguyen Hoan Phu, Nguyen Ngoc Quyen,
Cao Quang Thai, Tran Tinh Hien, Laurens Manning, Moses Laman, Peter Siba,
Harin Karunajeewa, Steve Allen, Angela Allen, Timothy ME Davis, Pascal
Michon, Ivo Mueller, Sı´le F Molloy, Susana Campino, Angeliki Kerasidou,
Victoria J Cornelius, Lee Hart, Shivang S Shah, Gavin Band, Chris CA
Spencer, Tsiri Agbenyega, Eric Achidi, Ogobara K Doumbo, Jeremy Farrar,
Kevin Marsh, Terrie Taylor, Dominic P Kwiatkowski, MalariaGEN Consortium.
Characterisation of the opposing effects of G6PD deficiency on cerebral
malaria and severe malarial anaemia eLife 2017;6:e15085
28067620/ PMC5222559.
- Thao LTP, Heemskerk AD, Geskus RB, Mai NTH, Ha DTM, Chau TTH, Phu NH, Chau NVV, Caws M, Lan NH, Thu DDA, Thuong NTT, Day J, Farrar JJ, Torok E, Bang ND, Thwaites GE, Wolbers M. Prognostic models for 9 month mortality in tuberculous meningitis. Clin Infect Dis. 2017 Sep 26. doi: 10.1093/cid/cix849.
- Torok ME, Aljayyoussi G, Waterhouse D, Chau TTH, Mai NTH, Phu NH, Hien TT, Hope W, Farrar JJ, Ward SA. Suboptimal Exposure to Anti-TB Drugs in a TBM/HIV+ Population Is Not Related to Antiretroviral Therapy.
Clin Pharmacol Ther.2017 Feb 4. doi: 10.1002/cpt.646.
- Srinivasan Vijay, Vinh DN, Hai HT, Ha VTN, Dung VTM, Dinh TD, Nhung HN,Tram TTB, Aldridge BA, Hanh NT, Thu DDA, Phu NH, Thwaites GE, Thuong NTT. Influence of Stress and Antibiotic Resistance on Cell-Length Distribution in Mycobacterium tuberculosis clinical isolates. Front. Microbiol. 8:2296. doi: 10.3389/fmicb.2017.02296.
- Mai NTH, Phu NH, Nghia HDT, Phuong TM, Duc DT, Chau NVV, Wills B, Tchoyoson LCC, Thwaites G, Simmons CP, Yacoub S. Dengue-associated posterior reversible encephalopathy syndrome, Vietnam. Emerg Infect Dis. Vol. 24, No. 2, February 2018.
- Srinivasan Vijay, Hai HT, Thu DDA, Johnson E, Pielach A, Phu NH, Thwaites GE, Thuong NTT. Ultrastructural Analysis of Cell Envelope and Accumulation of Lipid Inclusions in linical Mycobacterium tuberculosis Isolates from Sputum, Oxidative Stress, and Iron Deficiency. 11 January 2018 | https://doi.org/10.3389/fmicb.2017.02681.
- Mai NT, Dobbs N, Phu NH, Colas RA, Thao LTP, Thuong NTT, Nghia HDT, Hanh NHH, Hang NT, Heemskerk AD, Day JN, Ly L, Thu DDA, Merson L, Kestelyn E, Wolbers M, Geskus R, Summers D, Chau NVV, Dalli J, Thwaites GE. A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults.
eLife 2018;7:33478.
- Loan HT, Yen LM, Kestelyn E, Van Hao N, Mai NTH, Thuy DB, Hai Duong HT, Dung NTP, Phu NH, Lieu PT, Thanh TT, Geskus R, Rogier van Doorn H, Van Tan L, Wyncoll D, , Hien TT, Thwaites GE, Chau NVV, Thwaites CL. A pilot study to assess safety and feasibility of intrathecal immunoglobulin for the treatment of adults with tetanus. Am J Trop Med Hygiene. 2018 Jun 18. doi: 10.4269/ajtmh.18-0153.
- Tram TTB, Nhung HN, Vijay S, Hai HT, Thu DDA, Ha VTN, Dinh TD, Ashton PM, Hanh NT, Phu NH, Thwaites GE, Thuong NTT. Virulence of Mycobacterium tuberculosis Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages and Cytokine Response. Frontiers in Cellular and Infection Microbiology November 2018 | Volume 8 | Article 417.
- Hai HT, Vinh DN, Thu DDA, Hanh NT, Phu NH, Srinivasaba V, Thwaites GE, Thuong NTT. Comparison of the Mycobacterium tuberculosis molecular bacterial load assay, microscopy and GeneXpert versus liquid culture for viable bacterial load quantification before and after starting pulmonary tuberculosis treatment. Tuberculosis. Vol 119, Dec 2019, 101864.
- Donovan J, Figaji A, Imran D, Phu NH, Rohlwink U, Thwaites GE. The neurocritical care of tuberculous meningitis.
Lancet Neurol 2019 May 17, 2019 http://dx.doi.org/10.1016/ S1474-4422(19)30154-1.
- Hong NTT, Nghia HDT, Thanh TT, Lan NPH, Ny NTH, Ngoc NM, Hang VTT, Chau LTM, Quynh VTX, Diem LT, Hanh BTB, Hanh NHH, Duc DT, Man DNH, Campbell J, Oanh PKN, Day J, Phu NH, hau NVV, Thwaites G, Tan LV. Cerebrospinal fluid MinION sequencing of 16S sRNA gene for rapid and accurate diagnosis of bacterial meningitis. J Infect.2019 Dec 28 PMID 31891725.
- Leopold SJ, Watson JA, Jeeyapant A, Simpson JA, Phu NH, Hien TT, Day NPJ, Dondorp AM, White NJ. Ivestigating causal pathways in severe falciparum malaria: A pooled retrospective analysis of clinical studies. PloS Med. 2019 Aug 23;16(8):e 1002858 PMID: 31442221.
- Ding J, Thuong NTT, Toi PV, Heemskerk D, Pouplin T, Chau TTH, Mai NTH, Phu NH, Loc PP, Chau NVV, Thwaites G, Tarning J. Pharmacokinetics and pharmacodynamics of intensive anti-tuberculosis treatment of tuberculous meningitis. Clin Pharmacol Ther. 2020 Jan 19. Doi:10.1002/cpt.1783.31956998.
- Colas RA, Nhat LTH, Thuong NTT, Gomez EA, Ly L, Tyhanh HH, Mai NTH, Phu NH, Thwaites GE, Dalli J. Propresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous menigitis. FASEB. 2019 Sep 7:fj201901590R. PMID: 31500466.
- Hong NTT, Anh NT, Mai NTH, Nghia HDT, Nhu LNT, Thanh TT, Phu NH, Deng X, Doorn HRV, Chau NVV, Delwart E, Thwaites G, Tan LV. Performance of metagenomic next-generation sequencing for the diagnosis of viral meningoencephalitis in a resource limited setting. OFID. 2020; DOI: 10.1093/ofid/ofaa046.
- Donovan J, Thu DDA, Phu NH, Dung VTM, Quang TP, Nghia HDT, Oanh PKN, Nhu TB, Chau NVV, Ha VTN, Hang VTT, Trinh DHK, Geskus RB, Tan LV, Thuong NTT, Thwaites GE. Xpert MTB/FIF Ultra versus Xpert MTB/RIF for the diagnosis of tuberculous meningitis – a prospective, randomized, diagnostic accuracy study. Lancet Infect Dis 2020;
20: 299-307.
- Srinivasan V, Nhung HN, Bao NLH, Thu DDA, Trieu PT, Phu NH, Thwaites GE, Javid B, Thuong NTTT. Most-Probable-Number-Based Minimum Duration of Killing Assay for Determining the Spectrum of Rifampicin Susceptibility in Clinical Mycobacterium tuberculosis Isolates. Antimicrob Agents Chemother 2021; 65:e01439-20.
https://doi.org/10.1128/AAC.01439-20.
- Hong NTT, Nghia HDT, ThanhTT, Ny NTH, Ngoc NM, Hang VTT, Chau LTM, Quynh VX, Diem LT, Hanh BTB, Hanh NHH, Duc DT, Man DNH, Campbell J, Oanh PKN, Day J, Phu NH, Chau NVV, Thwaites G, Tan LV. Cerebrospinal fluid MinION sequencing of 16S rRNA gene for rapid and accurate diagnosis of bacterial meningitis. Letters to the Editor / Journal of Infection 80 (2020) 469–496.
Key responsibilities
- Vice Head, Department of Infectious Diseases, School of Medicine, Vietnam National University, Ho Chi Minh city, Viet Nam.
Professional engagement
- 10/2016 – present: Vice Head, Department of Infectious Diseases, School of Medicine, Vietnam National University, Ho Chi Minh city, Viet Nam;
- 6/2019 – present: Study Doctor and Collaborator, Oxford University Clinical Research Unit, Viet Nam;
- 2/2014 – 10/2016: Vice Head, Department of Microbiology and Parasitology, School of Medicine, Vietnam National University, Ho Chi Minh city, Viet Nam;
- 7 8/2004: WHO Short-term Consultant on Malaria in North Korea;
- 7 8/2003: WHO Short-term Consultant on Malaria in North Korea;
- 4 6/2002: World Health Organization (WHO) Short-term Consultant on Malaria in North Korea;
- 1991 – 4/2019: Senior Physician and Clinical Researcher, Oxford University Clinical Research Unit, Viet Nam & Vice Head, Vietnam British Infectious Diseases Ward, Hospital for Tropical Diseases, HCM City, Viet Nam;
- 1986 – 1991: Clinical Lecturer, Department of Infectious Diseases, Faculty of Medicine, University of Medicine and Pharmacy of HCM City, Viet Nam.
